Bone Abstracts

Infections within or in the vicinity of the skeleton induce osteolytic diseases such as periodontitis, septic arthritis, osteomyelitis. Although host production of osteotropic cytokines is crucial, the precise mechanism by which pathogen associated molecular patterns induce osteoclastogenesis and bone loss is not fully understood. Recognition of these molecules by pattern recognition receptors is highly preserved through evolution with trans-membrane Toll-like receptor (TLR) f...

RANKL induced osteoclastogenesis is mediated by several transcription factors such as NF-κB, AP-1 and Nfatc1. We have found that also cysteine proteinases are involved in the signaling pathway downstream RANK. Thus, cystatin C, Z-RLVG-CHN2 (the sequence of which is based upon one of the enzyme inhibitory domains in cystatin C) and the fungal molecule E-64 – inhibit RANKL induced mouse and human osteoclast formation in vitro (Strålberg et ...